A live-attenuated chlamydial vaccine protects against trachoma in nonhuman primates

A live-attenuated chlamydial vaccine protects against trachoma in nonhuman primates

Blinding trachoma is an ancient neglected tropical disease caused by Chlamydia trachomatis for which a vaccine is needed. We describe a live-attenuated vaccine that is safe and efficacious in preventing trachoma in nonhuman primates, a model with excellent predictive value for humans. Cynomolgus macaques infected ocularly with a trachoma strain deficient for the 7.5-kb conserved plasmid present...

Immunogenicity and Protective Efficacy of a Live Attenuated H5N1 Vaccine in Nonhuman Primates

The continued spread of highly pathogenic H5N1 influenza viruses among poultry and wild birds, together with the emergence of drug-resistant variants and the possibility of human-to-human transmission, has spurred attempts to develop an effective vaccine. Inactivated subvirion or whole-virion H5N1 vaccines have shown promising immunogenicity in clinical trials, but their ability to elicit prote...

Protects Nonhuman Primates against Hendra Virus Challenge

3 Chad E. Mire, Joan B. Geisbert, Krystle N. Agans, Yan-Ru Feng, Karla A. Fenton, 4 Katharine N. Bossart, Lianying Yan, Yee-Peng Chan, Christopher C. Broder and Thomas W. 5 Geisbert 6 7 Galveston National Laboratory and Departments of Microbiology and Immunology, University 8 of Texas Medical Branch, Galveston, Texas, USA; Department of Microbiology and 9 Immunology, Uniformed Services Universi...

A review of prophylactic measure against brucellosis in human with a live attenuated vaccine

Chikungunya vaccine candidate is highly attenuated and protects nonhuman primates against telemetrically monitored disease following a single dose.

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes major epidemics of rash, fever, and debilitating arthritis. Currently, there are no vaccines or antivirals available for prevention or treatment. We therefore generated 2 live-attenuated vaccine candidates based on the insertion of a picornavirus internal ribosome entry site (IRES) sequence into the genome of CHIKV. Vaccinatio...